Phase 2 data show Eli Lilly's tirzepatide (Mounjaro) combined with experimental eloralintide delivered 23.3% average weight loss in type 2 diabetes patients over 48 weeks, outperforming tirzepatide alone and improving HbA1c. The results strengthen Lilly's obesity/diabetes pipeline narrative and competitive positioning in incretin therapies, though higher GI side effects and elevated dropout rates introduce tolerability and execution risk ahead of larger trials.
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Phase 2 trial results showed Eli Lilly’s tirzepatide (Mounjaro) combined with an experimental drug produced an average 23.3% weight loss over 48 weeks in overweight or obese adults with type 2 diabetes. That compared with 14.8% for the highest dose of tirzepatide alone. The study enrolled 367 adults with an average starting weight of about 105kg.